15 Interactions de type instructif : A sur B donne XEn absence de A, B ne donne pas XEn présence de C, B donne YInteractions de type permissif :B a tout le nécessaire pour donner X;Il faut seulement un signal de progression
47 (Sprouty)(Similar expression to Fgfs)(MAP-kinase-phosphatase 3)(Isthmic organizer)Brain Res Rev (2005)
48 (Heparan sulfate proteoglycan) Figure 1 Model of interaction between FGF, its receptor, and the proteoglycan carbohydrate groups. Data support the hypothesis that HSPGs modulate the binding of FGF-2 to FGFR through the formation of a ternary complex in which the glycosaminoglycan chain interactswith FGF-2 via 2-O- and N-sulfate groups while 6-O-sulfate groups are required for its interaction with FGFR. A single molecule of heparin/HS may bind several molecules of FGF-2 suggesting that GAG induces oligomerization of FGF-2. (After Presta, M. 2000).
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