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Lab meeting 01/11/2018. DNA methylation DNA methylation is one of the most commonly occurring epigenetic events taking place in the mammalian genome.

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Présentation au sujet: "Lab meeting 01/11/2018. DNA methylation DNA methylation is one of the most commonly occurring epigenetic events taking place in the mammalian genome."— Transcription de la présentation:

1 Lab meeting 01/11/2018

2 DNA methylation DNA methylation is one of the most commonly occurring epigenetic events taking place in the mammalian genome. This change, though heritable, is reversible, making it a therapeutic target. Methylation pattern is determined during embryogenesis and passed over to differentiating cells and tissues. Addition of methyl group to C-5 position of cytosine residues. Most cytosine methylation occurs in the sequence context 5'CG3‘ Occurs almost exclusively at cytosines that are followed immediately by a Guanine- CpG Dinucleotide

3 Mechanism Methyl groups are transferred from S-adenosyl methionine in a reaction catalysed by a DNA methyl-transferases(DNMT) or methylases.

4 CpG Islands CpG islands (CGI) are genomic regions that contain a high concentration of CpG sites

5 Conversion of unmethylated cystosines to uracil using sodium bisulfite

6

7 DNA Marker U MU M UM POMC PPMOPR PPDOPR PP 300 bp 200 bp DNA Marker U MU M UM POMC PPMOPR PPDOPR PP 300 bp 200 bp A B

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