Nanoparticles for treating brain cancer REALIZED BY: EL MANSOURI ABDESSAMAD SUPERVISED BY: Pr AAMOUUCH.

Slides:



Advertisements
Présentations similaires
What is the nanotechnology History applications of nanotechnology Conclusion.
Advertisements

I can tell time in French!
© CEA Tous droits réservés. Toute reproduction totale ou partielle sur quelque support que ce soit ou utilisation du contenu de ce document est interdite.
NAME: Abdul Saleem Mir Enrollment Number: 49/2010 7th ELECTRICAL
%mass %volume Composition of concrete Concrete cement water sand
Français 1: Chapitre 3: Tout pour la rentrée. CHAPTER 3: TOUT POUR LA RENTREE  In this chapter, you will learn to: Make and respond to requests Ask others.
PIPE SUPPORTS 1 Pipe supports inside the compression station and pumping stations AUGUST 2014.
« Petit Suisse » Nutrition value Packaging Price.
IP Multicast Text available on
Template Provided By Genigraphics – Replace This Text With Your Title John Smith, MD 1 ; Jane Doe, PhD 2 ; Frederick Smith, MD, PhD 1,2 1.
UNEP / ICCA Workshop TEMA June DG and GHS Classification System.
Subject: CMS(Content Management System) Université Alioune DIOP de Bambey UFR Sciences Appliquées et Technologies de l’Information et de la Communication.
WASTE WATER AND ITS TREATMENT IN TEXTILE INDUSTRY VANDANA TRIPATHI.
MALARIA.  PLAN I.Public health importance II.Definition III.Signs and symptoms of Malaria IV.Mechanism and causes of Malaria V.Complications of Malaria.
jeudi, le quatorze septembre
Reference Document Document de référence
Point de départ The verb avoir (to have) is used frequently. You will have to memorize each of its present tense forms because they are irregular.
Contractions with à and de
Speaking Exam Preparation
The nation now known as The Democratic Republic of Congo was at one time the personal property of the King of Belgium.
How many young people? Young people take drugs
Venir de.
mardi, le douze septembre
Cross Cutting Mapping Project
—Je doute que tu te sois dépêché de rentrer…
Samples for evaluation from All Charts & Templates Packs for PowerPoint © All-PPT-Templates.comPersonal Use Only – not for distribution. All Rights Reserved.
Quantum Computer A New Era of Future Computing Ahmed WAFDI ??????
- User case - 3D curve length optimization
Statistics & Econometrics Statistics & Econometrics Statistics & Econometrics Statistics & Econometrics Statistics & Econometrics Statistics & Econometrics.
Innovative Plants For a green and technologic future.
There are so many types of sports. For example-: Basketball,volleyball, cricket, badminton, table tennis, football, lawn tennis etc.
NFPA-12 Edition 2005 What “IMPACT” will the changes to NFPA-12 have on the design and installation of a CO 2 system?
INVERTER LOAD SPEED CONTROLLER Power demand Speed reference ENGINE 230/400V 50Hz/60Hz PMGPMG 1 f = Hz Speed =var Island Operation of the Adjustable.
Copyright 2007 – Biz/ed Globalisation.
P&ID SYMBOLS. P&IDs Piping and Instrumentation Diagrams or simply P&IDs are the “schematics” used in the field of instrumentation and control (Automation)
Leadership Styles Mrs. Keith Main Types of Leadership Styles 1.The Autocratic or Authoritarian Leader 2.The Democratic or Participative Leader.
NO x is a generic term for the nitrogen oxides that are most relevant for air pollution, namely nitric oxide (NO) and nitrogen dioxide (NO 2 ).These gases.
Integrated Gasification Combined Cycle Plant By Abhijit Kumar Prasad Submitted to Dr. B.Paul Assistant Professor MNNIT Allahabad.
Lect12EEE 2021 Differential Equation Solutions of Transient Circuits Dr. Holbert March 3, 2008.
High-Availability Linux Services And Newtork Administration Bourbita Mahdi 2016.
REMOVE EFFECTIVELY YOUR HOME WITH CHEKS ECO-ENERGY Win in quality of life and save on your electicity bills by realizing a renovation of your home.
The Passé Composé In the previous lesson we looked at the formation of the passé composé (perfect tense) with Avoir verbs. In this lesson we will further.
Contractions with à and de
Nous allons apprendre…
Cryopreservation. Benefits Of Freezing Cells Benefits Of Freezing A Validated Stock Of Cells –Genotypic drift –Senescence leading to extinction of cell.
Forum national sur l’IMT de 2004.
Grammar Flash Cards La révision.
Français II H – Unité Préliminaire A Structures
Point de départ In D’accord! Level 1, you learned how possessive adjectives function in French. You will now learn about possessive pronouns and how.
Question formation In English, you can change a statement into a question by adding a helping verb (auxiliary): does he sing? do we sing? did they sing.
WRITING A PROS AND CONS ESSAY. Instructions 1. Begin your essay by introducing your topic Explaining that you are exploring the advantages and disadvantages.
What’s the weather like?
Analyses thermiques Le comportement thermique a été tudié par ATG et ATD afin de prévoir la température et les conditions de calcination nécessaire à l'obtention.
Presented by : HAMDI Yosra Faculty of science of Bizerte 1 1.
POWERPOINT PRESENTATION FOR INTRODUCTION TO THE USE OF SPSS SOFTWARE FOR STATISTICAL ANALISYS BY AMINOU Faozyath UIL/PG2018/1866 JANUARY 2019.
From «Univer» to the state Duma. Made by Alice Berezovskaya. AF-44.
© by Vista Higher Learning, Inc. All rights reserved.4A.1-1 Point de départ In Leçon 1A, you saw a form of the verb aller (to go) in the expression ça.
Travail de cloche Translate into French: Although he was king, Louis XVI was lazy.
Travail de cloche Translate into French: The cows who give the most milk are those which eat the best grass.
Travail de cloche Quelle est votre station de ski préférée?
CELL DYNAMICS IN SOME BLOOD DISEASES UNDER TREATMENT
Avoiding the Pitfalls of Bad Slides Tips to be Covered Outlines Slide Structure Fonts Colour Background Graphs Spelling and Grammar Conclusions Questions.
Les négatifs et l’interrogation
A. André1,2 ; A. Mouton1 ; V. Millien2 ; J. Michaux1
University : Ammar Telidji Laghouat Faculty : Technology Department : Electronics 3rd year Telecommunications Professor : S.Benghouini Student: Tadj Souad.
CRCINA : Histoire et Géographie
Prepositions of location and disjunctive pronous
D’Accord 1 Leçon 3A.1 Descriptive adjectives (irregular adjectives, adjective placement-BAGS, and physical description.)
Prepositions of Location
Les Jours de la Semaine ©  Copyright Kapow! 2017.
Transcription de la présentation:

Nanoparticles for treating brain cancer REALIZED BY: EL MANSOURI ABDESSAMAD SUPERVISED BY: Pr AAMOUUCH

PLAN INTRODUCTION * Molecular physiology of the BBB * Diseas related to BBB THE BLOOD BREAN BARRIER DRUG DELIVERY TO THE BRAIN COLLOIDAL CARRIERES CONCLUSION * MATERAIALS USED * MECHANISM OF TRANSAPORT * TARGETTING NANOPATRICLES 06 * Emulsion polymerization POLY(alkylcyanoacrylates) 07

INTRODUCTION

THE BLOOD BRAIN BARRIER Molecular physiology of the BBB

DRUG DELIVERY TO THE BRAIN The diffusion of a drug from the blood into the brain is mainly dependent on its ability to enter the BCECs. This is correlated with physicochemical properties such as optimised lipophilicity, low molecular size, and a neutral or negative charge, or the appropriate domain for interaction with a receptor or a carrier required to cross the BBB disrupt the BBB modify the drug characteristics use colloidal carriers

COLLOIDAL CARRIERS  Colloidal carriers consist of lipidic or polymeric particles, in which the drug is adsorbed, entrapped, or encapsulated. These include liposomes and nanoparticles.  they respond to ideal characteristics of biocompatibility, biodegradability, physical stability in the blood  they mask the drug’s physico-chemical properties USE OF COLLOIDAL DRUG CARRIERS

NANOPARTICLES The size ranging from 1 to 1000 nm and it include both ; nanocapsules (reservoir systeme) and nanospheres (a matix systeme)

NANOPARTICLES different methods developed for the preparation of nanoparticles.

EMULSION POLYMERIZATION 123 single monomer units of a given compound Once polymerization is complet e, the solution is filtered and neutralized to remove any residual monomers. Triggers for polymer grow th include high-energy radiation, UV light, or hydroxyl ions Polymerization occurs spontaneously at room temperature after initiation by either free radical or ion formation.

NANOPARTICLES Materials used Polycetates,acylic co-polymers, Poly(lactide)(PLGA) poly(alkylcyanacylates)(PACA) Poly(D-,l-lactido-glycocide)  polysobate coated nanparticles can mimic LDL to across the BBB  polyxyethylene sorbitan monooleate coated NPs containing drug easily across the BBB  Radiolabel polythylene glycole coated hexadecyanoacylate nanosphers Mechanism of transportTargetting The coating of PACA or PLGA with polysorbate 80 or polyxamer 188 The NPs adbsorb apoli poproteins E or A(-1) fr om the blood Iteract with LRP1 or wit h the scavenger recept or followed by trasytosi s across the BBB ADHESION FLUIDIZATION OF BB B ENDETHELIUM BY SURFACTANTS OPENING OF TIGHT JUNCTION TRANSCYTOSIS/END OSCYTOSis BLOCKAGE OF G LYCOPROTEIN

POLY(alkylcyanoacrylates) It’s a monomers considered as materials for biomedical applications. (PACAs) were not employed as polymers until the early 1980s. PACA NPs was coated with polysorbate 80 have been proposed to overcome the BBB and deliver drugs to the brain

POLY(alkylcyanoacrylates) MONOMER PACA

Example of this procedure ùl of monomer. PACA allowed to polymerize spontaneously for a few hours (3–4 h) under strong magnetic stirring. dispersed in acidified water containing a surfactant or a stabilizing agent (10 ml of a 0.5–1% solution of PluronThe additi on of cyclodextrins to theic F68 or dextr an 70 proat pH 2.5 adjusted with HCl). The addition of cyclodextrins to the polymerization medium can promote the association of poorly water-soluble drugs with the PACA nanos-pheres.

Disease related to BBB

CONCLUSION After 30 years of research on polymeric NPs, this delivery system practically does not exist clinically, yet NPs appear to have significant potential in delivering drugs to the brain.

Thank you FOR YOUR ATTENTION

REFERRENCES Article :GARCEL, Aude, et al. In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosystems. International Journal of Biomedical Nanoscience and Nanotechnology, 2010, vol. 1, no. 2/3/4, p Article : Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer’s diseaseB Article : Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier Article : Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications