Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer- Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain) 

Présentation au sujet: "Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer- Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain) "— Transcription de la présentation:

1 Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer- Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain)  Philippe Poulain, Marie-Pierre Berleur, Shimsi Lefki, Danièle Lefebvre, Gisèle Chvetzoff, Eric Serra, Fibra Tremellat, Alain Derniaux, Marilène Filbet A. Simon, B. Dang Vu, C. Guillaume, S. Laurent, B. George, O. Dubroecq, D. Dupoiron, D. Mayeur, M. Montagne, B. Devalois, P. Brillaxis, N. Saffon Philippe Poulain, Marie-Pierre Berleur, Shimsi Lefki, Danièle Lefebvre, Gisèle Chvetzoff, Eric Serra, Fibra Tremellat, Alain Derniaux, Marilène Filbet A. Simon, B. Dang Vu, C. Guillaume, S. Laurent, B. George, O. Dubroecq, D. Dupoiron, D. Mayeur, M. Montagne, B. Devalois, P. Brillaxis, N. Saffon  Journal of Pain and Symptom Management  Volume 52, Issue 5, Pages e1 (November 2016) DOI: /j.jpainsymman Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

2 Fig. 1 Flow chart. Group A: stop-and-go method (n = 71), Group B: progressive method (n = 73). ITT = intent to treat; PP = per protocol. Journal of Pain and Symptom Management  , e1DOI: ( /j.jpainsymman ) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

3 Fig. 2 Main pain intensity score over time ITT set. Group A: stop-and-go method (n = 71), Group B: progressive method (n = 73). ITT = intent to treat. Journal of Pain and Symptom Management  , e1DOI: ( /j.jpainsymman ) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

4 Fig. 3 Patient distribution according to the total daily methadone dose. Group A: stop-and-go method (n = 71), Group B: progressive method (n = 73). Journal of Pain and Symptom Management  , e1DOI: ( /j.jpainsymman ) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

5 Supplementary Data Equianalgesic conversion chart.
Journal of Pain and Symptom Management  , e1DOI: ( /j.jpainsymman ) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions