L'impact du vaccin antirotavirus | Tableaux Tous les tableaux sur limpact des vaccins antirotavirus peuvent être téléchargés. Les vaccins antirotavirus permettent des réductions significatives de la diarrhée sévère et mortelle chez les enfants vaccinés et non vaccinés Les vaccins anti-rotavirus sauvent des vies et améliorent la santé dans les pays où les enfants y ont accès. Une baisse rapide et significative des hospitalisations et des décès dus à la diarrhée causée par le rotavirus et provenant dautres causes a été observée dans la plupart des pays qui ont introduit les vaccins antirotavirus dans leurs programmes nationaux de vaccination. Les chercheurs ont aussi constaté que l'utilisation des vaccins antirotavirus peut protéger les enfants et les adultes non vaccinés en réduisant la transmission du rotavirus de la population vaccinée aux membres non vaccinés de la communauté (un effet appelé immunité grégaire). Ces résultats remarquables soulignent le potentiel incroyable des vaccins antirotavirus dans lamélioration de la santé infantile et pour sauver des vies d'enfants.

Tableau 1. Impact des vaccins antirotavirus sur les hospitalisations dues aux gastroentérites à rotavirus chez les enfants de <5 ans.

Tableau 1 références 1.Tate JE, Panozzo CA, Payne DC, et al. Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine. Pediatrics. 2009;124:465– Yen C, Tate JE, Wenk JD, Harris JM 2nd, Parashar UD. Diarrhea-associated hospitalizations among US children over 2 rotavirus seasons after vaccine introduction. Pediatrics. 2011;127:e9–e15. 3.Tate JE, Mutuc JD, Panozzo CA, et al. Sustained decline in rotavirus detections in the United States following the introduction of rotavirus vaccine in Pediatric Infectious Disease Journal. 2011;30(suppl 1):S30–S34. 4.Buttery JP, Lambert SB, Grimwood K, et al. Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australias National Childhood vaccine schedule. Pediatric Infectious Disease Journal. 2011;30(suppl 1):S25–S29. 5.Braeckman T, Van Herck K, Raes M, Vergison A, Sabbe M, Van Damme P. Rotavirus vaccines in Belgium: policy and impact. Pediatric Infectious Disease Journal. 2011;30(suppl 1):S21–S24. 6.Raes M, Strens D, Vergison A, Verghote M, Standaert B. Reduction in pediatric rotavirus-related hospitalizations after universal rotavirus vaccination in Belgium. Pediatric Infectious Disease Journal. 2011;30: e120–e25. 7.Paulke-Korinek M, Rendi-Wagner P, Kundi M, Kronik R,Kollaritsch H. Universal mass vaccination against rotavirus gastroenteritis: impact on hospitalization rates in Austrian children. Pediatric Infectious Disease Journal. 2010;29:319– Paulke-Korinek M, Kundi M, Rendi-Wagner P, et al. Herd immunity after two years of the universal mass vaccination program against rotavirus gastroenteritis in Austria. Vaccine. 2011;29:2791–2796

Tableau 2: Impact des vaccins contre le rotavirus sur les hospitalisations pour toutes causes de gastroentérite aiguë chez les enfants de <5 ans.

Tableau 2 références 1.Curns AT, Steiner CA, Barrett M, Hunter K, Wilson E, Parashar UD. Reduction in acute gastroenteritis hospitalizations among US children after introduction of rotavirus vaccine: analysis of hospital discharge data from 18 US states. Journal of Infectious Disease. 2010; 201:1617– Cortese MM, Tate JE, Simonsen L, Edelman L, Parashar UD. Reduction in gastroenteritis in United States children and correlation with early rotavirus vaccine uptake from national medical claims databases. Pediatric Infectious Disease Journal. 2010;29:489– Yen C, Tate JE, Wenk JD, Harris JM 2nd, Parashar UD. Diarrhea-associated hospitalizations among US children over 2 rotavirus seasons after vaccine introduction. Pediatrics. 2011;127:e9–e15. 4.Raes M, Strens D, Vergison A, Verghote M, Standaert B. Reduction in pediatric rotavirus-related hospitalizations after universal rotavirus vaccination in Belgium. Pediatric Infectious Disease Journal. 2011;30: e120–e25. 5.Lanzieri TM, Costa I, Shafi FA, et al. Trends in hospitalizations from all-cause gastroenteritis in children younger than 5 years of age in Brazil before and after human rotavirus vaccine introduction, 1998–2007. Pediatric Infectious Disease Journal. 2010;29:673– do Carmo GM, Yen C, Cortes J, Siqueira AA, de Oliveira WK, Cortez-Escalante JJ, et al. Decline in diarrhea mortality and admissions after routine childhood rotavirus immunization in Brazil: a time-series analysis. PLoS Medicine. 2011;8(4):e Quintanar-Solares M, Yen C, Richardson V, Esparza-Aguilar M, Parashar UD, Patel MM. Impact of rotavirus vaccination on diarrhea-related hospitalizations among children <5 years of age in Mexico. Pediatric Infectious Disease Journal. 2011;30(suppl 1):S11–S15. 8.Yen C, Armero Guardado JA, Alberto P, et al. Decline in rotavirus hospitalizations and health care visits for childhood diarrhea following rotavirus vaccination in El Salvador. Pediatric Infectious Disease Journal. 2011;30 (suppl 1):S6–S10.

Tableau 3. Impact des vaccins antirotavirus sur les décès dus à toutes causes de gastro-entérites aiguës chez les enfants de <5 ans. 1 Lanzieri TM, Linhares AC, Costa I, et al. Impact of rotavirus vaccination on childhood deaths from diarrhea in Brazil. International Journal of Infectious Diseases. 2011;15(3):e206-e do Carmo GM, Yen C, Cortes J, Siqueira AA, de Oliveira WK, Cortez-Escalante JJ, et al. Decline in diarrhea mortality and admissions after routine childhood rotavirus immunization in Brazil: a time-series analysis. PLoS Medicine. 2011;8(4):e Richardson V, Hernandez-Pichardo J, Quintanar-Solares M, Esparza-Aguilar M, Johnson B, Gomez-Altamirano CM, et al. Effect of rotavirus vaccination on death from childhood diarrhea in Mexico. The New England Journal of Medicine. 2010;362(4): Richardson V, Parashar U, Patel M. Childhood diarrhea deaths after rotavirus vaccination in Mexico. The New England Journal of Medicine. 2011;365(8):

Tableau 4: Bénéfices indirects de la vaccination contre le rotavirus (immunité grégaire).

Tableau 4 références 1.Cortese MM, Tate JE, Simonsen L, Edelman L, Parashar UD. Reduction in gastroenteritis in United States children and correlation with early rotavirus vaccine uptake from national medical claims databases. Pediatric Infectious Disease Journal. 2010;29:489– Yen C, Tate JE, Wenk JD, Harris JM 2nd, Parashar UD. Diarrhea-associated hospitalizations among US children over 2 rotavirus seasons after vaccine introduction. Pediatrics. 2011;127:e9–e15. 3.Field EJ, Vally H, Grimwood K, Lambert SB. Pentavalent rotavirus vaccine and prevention of gastroenteritis hospitalizations in Australia. Pediatrics. 2010;126:e506– Raes M, Strens D, Vergison A, Verghote M, Standaert B. Reduction in pediatric rotavirus-related hospitalizations after universal rotavirus vaccination in Belgium. Pediatric Infectious Disease Journal. 2011;30: e120–e25. 5.Paulke-Korinek M, Kundi M, Rendi-Wagner P, et al. Herd immunity after two years of the universal mass vaccination program against rotavirus gastroenteritis in Austria. Vaccine. 2011;29:2791– Safadi MA, Berezin EN, Munford V, et al. Hospital-based surveillance to evaluate the impact of rotavirus vaccination in São Paulo, Brazil. Pediatric Infectious Disease Journal. 2010;29:1019– Yen C, Armero Guardado JA, Alberto P, et al. Decline in rotavirus hospitalizations and health care visits for childhood diarrhea following rotavirus vaccination in El Salvador. Pediatric Infectious Disease Journal. 2011;30 (suppl 1):S6–S10.