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IeDEA West Africa WADA: West Africa database on antiretroviral therapy Charlotte Lewden Médecin épidémiologiste, ISPED, Inserm U897, Université de Bordeaux,

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Présentation au sujet: "IeDEA West Africa WADA: West Africa database on antiretroviral therapy Charlotte Lewden Médecin épidémiologiste, ISPED, Inserm U897, Université de Bordeaux,"— Transcription de la présentation:

1 IeDEA West Africa WADA: West Africa database on antiretroviral therapy Charlotte Lewden Médecin épidémiologiste, ISPED, Inserm U897, Université de Bordeaux, France

2 IeDEA West Africa, 5 June IeDEA International Epidemiologic Databases to Evaluate AIDS International research consortium established in 2005 by the US National Institute of Allergy and Infectious Diseases (NIH) Resource for globally diverse HIV/AIDS data To address research questions in HIV/AIDS unanswerable by single cohorts First round ; Second round : currently year 7: July 2012 to June 2013

3 IeDEA West Africa, 5 June IeDEA Regions

4 IeDEA West Africa, 5 June WADA: 16 adult and 11 pediatric centres in 9 countries: Benin, Burkina Faso, Côte dIvoire, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal, Togo Coordinating Center: ISPED, Univ Bordeaux Segalen, France Regional Office: PAC-CI, CHU Treichville, Abidjan Côte dIvoire IeDEA West Africa (WADA)

5 IeDEA West Africa, 5 June WADA Objectives for To measure the effectiveness of ART in HIV-infected individuals in West Africa in the long-term, and to assess factors that influence program and treatment outcomes To increase the capacity for delivering ART durably in West Africa by increasing the capacity for monitoring clinical outcomes at the individual and population levels in adults and children To document the morbidity burden in HIV-infected individuals in care in HIV programs throughout West Africa.

6 IeDEA West Africa, 5 June WADA study design Observational prospective multicenter study Pooled database of HIV-infected adults and children data followed in reference clinics in West Africa

7 IeDEA West Africa, 5 June WADA Sites CountryAdultsChildren Benin11urban Burkina Faso21urban Cote dIvoire65urban, 2 semi-rural Ghana1urban Guinea Bissau1urban Guinee Conakryfuturesemi-rural Mali21urban Nigeria2urban Senegal11urban Togo11urban

8 IeDEA West Africa, 5 June WADA Inclusion criteria –HIV-1 or HIV-2 infected –Treatment with ART (antiretroviral combinations) –HIV-infected individuals who initiated ART –HIV-2 or HIV-1/HIV-2 infected individuals >18 years, whatever they receive ART or not –HIV-exposed children born to HIV-infected mothers until their early infant HIV diagnosis –Children with a confirmed HIV-infection whatever the time of ART initiation

9 IeDEA West Africa, 5 June WADA scientific update and perspectives Response to ART in adults Morbidity Hepatitis Cancer Quality of life HIV-2 and HIV-1/HIV-2 Pediatrics and adolescents Women and mothers (Linkage to care and in care)

10 IeDEA West Africa, 5 June IeDEA West Africa Observational cohort HIV-infected adults with ART N= 58,611 HIV-2 or (HIV-2 and HIV-1) positive N= 1,933 HIV-exposed children N= 4,079 HIV-infected children without ART N= 526 HIV-infected children with ART N= 4,808

11 IeDEA West Africa, 5 June Tables DescriptionPediatricsAdults Socio-demographic and clinical characteristics at ART initiation /baseline TAB_BAS Biological data (baseline and follow-up)TAB_LAB TCD4+ lymphocytes measurements (baseline and follow-up) TAB_LAB_CD4TAB_LABCD4 Viral load measurements (baseline and follow-up)TAB_LAB_RNATAB_LABCV Antiretroviral treatments (ART)TAB_ARTTAB_MISEART TAB_SUIART Follow-upTAB_VISTAB_SUIVI Vital status, date of last contactTAB_OUTCOMETAB_STATUT MTCTTAB_PMTCT_INTTAB_PTME Opportunistic infections-TAB_IO Prophylaxies of opportunistic infections-TAB_PROPHYIO Parental healthTAB_PAR_HEALTH-

12 IeDEA West Africa, 5 June Apport des bases de données pour le suivi des PVVIH Formalisation du recueil de données : fiche standard (pas toujours) Édition de liste de patients en retard de visite pour la relance active des patients perdus de vue Edition dhistoriques à partir du dossier du patient (pas toujours) ou visualisation du dossier informatisé pendant la consultation Aide à la décision Gestion de lapprovisionnement en tests et médicaments Rapports aux financeurs Suivi des pratiques, respect des recommandations Recherche Forster_Bul_WHO2008 (Art-Linc); Braitstein_jaids2009 (Kenya); Nash_jaids2009; Douglas_plosmed2010 (Malawi); Ekouevi_curr_opinin_hiv_aids2011

13 IeDEA West Africa, 5 June Sine qua non Personnels compétents et en nombre suffisant Maintenance du matériel Sauvegardes Complétude de la base Contrôle de la qualité

14 IeDEA West Africa, 5 June Inconvénients possibles Base de données incomplète donc inutilisable Redondance des fiches et des tables par ajouts successifs entrainant un surcroit de travail

15 IeDEA West Africa, 5 June


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