Efficacy of Sofosbuvir and Daclatasvir in Patients With Fibrosing Cholestatic Hepatitis C After Liver Transplantation Vincent Leroy, Jérôme Dumortier,

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Transcription de la présentation:

Efficacy of Sofosbuvir and Daclatasvir in Patients With Fibrosing Cholestatic Hepatitis C After Liver Transplantation Vincent Leroy, Jérôme Dumortier, Audrey Coilly, Mylène Sebagh, Claire Fougerou-Leurent, Sylvie Radenne, Danielle Botta, François Durand, Christine Silvain, Pascal Lebray, Pauline Houssel-Debry, Nassim Kamar, Louis D’Alteroche, Ventzislava Petrov-Sanchez, Alpha Diallo, Georges-Philippe Pageaux, Jean-Charles Duclos-Vallee Georges-Philippe Pageaux, Jean-Charles Duclos-Vallée, Audrey Coilly, Eric Bellissant, Danielle Botta-Fridlund, Alpha Diallo, Jérôme Dumortier, François Durand, Christophe Duvoux, Claire Fougerou-Leurent, Vincent Leroy, Ventzislava Petrov-Sanchez, Alain Renault, Alexandra Rohel, Anne-Marie Roque, Anne-Marie Taburet, Aurélie Veislinger Vincent Leroy, Jérôme Dumortier, Audrey Coilly, Mylène Sebagh, Claire Fougerou-Leurent, Sylvie Radenne, Danielle Botta, François Durand, Christine Silvain, Pascal Lebray, Pauline Houssel-Debry, Nassim Kamar, Louis D’Alteroche, Ventzislava Petrov-Sanchez, Alpha Diallo, Georges-Philippe Pageaux, Jean-Charles Duclos-Vallee Georges-Philippe Pageaux, Jean-Charles Duclos-Vallée, Audrey Coilly, Eric Bellissant, Danielle Botta-Fridlund, Alpha Diallo, Jérôme Dumortier, François Durand, Christophe Duvoux, Claire Fougerou-Leurent, Vincent Leroy, Ventzislava Petrov-Sanchez, Alain Renault, Alexandra Rohel, Anne-Marie Roque, Anne-Marie Taburet, Aurélie Veislinger Clinical Gastroenterology and Hepatology Volume 13, Issue 11, Pages 1993-2001.e2 (November 2015) DOI: 10.1016/j.cgh.2015.05.030 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Cumulative incidence of complete clinical response over time according to treatment regimen. No statistical difference was observed between the 2 arms. Clinical Gastroenterology and Hepatology 2015 13, 1993-2001.e2DOI: (10.1016/j.cgh.2015.05.030) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Evolution of AST, ALT, alkaline phosphatase (ALP), and γGT serum levels over time. Results are presented as median (circle) and IQR (bars). Clinical Gastroenterology and Hepatology 2015 13, 1993-2001.e2DOI: (10.1016/j.cgh.2015.05.030) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 1 Evolution of total bilirubin serum levels over time. Results are presented as medians (circle) and IQR (bars). Clinical Gastroenterology and Hepatology 2015 13, 1993-2001.e2DOI: (10.1016/j.cgh.2015.05.030) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 2 Early viral decay according to treatment regimen. No statistical difference was observed between the 2 arms. Clinical Gastroenterology and Hepatology 2015 13, 1993-2001.e2DOI: (10.1016/j.cgh.2015.05.030) Copyright © 2015 AGA Institute Terms and Conditions