Trend over calendar time in virological failure in HIV-infected patients treated for at least six months with combined antiretroviral therapy in France.

Présentation au sujet: "Trend over calendar time in virological failure in HIV-infected patients treated for at least six months with combined antiretroviral therapy in France."— Transcription de la présentation:

1 Trend over calendar time in virological failure in HIV-infected patients treated for at least six months with combined antiretroviral therapy in France (FHDH ANRS CO04) Constance DELAUGERRE 1, Jade GHOSN 2, Jean-Marc LACOMBE 3, Gilles PIALOUX 4, Lise CUZIN 5, Odile LAUNAY 6, Amélie MENARD 7, Pierre de TRUCHIS 8 and Dominique COSTAGLIOLA 3 for the FHDH –ANRS CO04 1-Virology, Paris Diderot University, St louis hospital, Paris 2-Infectious diseases, Paris Sud University, KB hospital, Kremlin Bicêtre 3-U943 INSERM and UPMC, Paris 4-Infectious Diseases, UPMC-Tenon hospital, Paris 5-Infectious Diseases, CHU Toulouse 6-Internal Medicine, Paris Descartes University, Cochin hospital, Paris 7-St Marguerite hospital, Marseille 8- Infectious Diseases, Versailles St Quentin en Yvelines University, R Poincare hospital, Garches abstract#TUPDB0104

2 Conflict of interest Dominique Costagliola has received travel grants, consultancy fees, honoraria or study grants from various pharmaceutical companies including Abbott, Boehringer- Ingelheim, Bristol-Myers-Squibb, Gilead Sciences, Glaxo-Smith-Kline, Janssen, Merck-Sharp & Dohme-Chibret, Roche and ViiV Healthcare

3 Characteristic of patients A total of 72978 patients were enrolled, with a median follow-up of 96 [49-150] months, corresponding to a median of 11 [6-21] viral load/patient (Table 1)

4 VF evolution between 1997-2009 pVL median copies/ml [IQR25-75] 7500 [1900-35825] 6000 [1700-28455] 5850 [1594-28530] 6160 [1590-31972] 4700 [1250-25552] 3414 [1032-23723] Figure 1

5 Adjusted on age, sex and group, geographical origin, HCV infection, AIDS, current CD4, type of ART at initiation, duration of cART, number of ARV received Figure 2

6 During the thirteen-year period from 1997 to 2009, percentage of patients experiencing VF under ART dramatically decreased The decrease of VF was significant between each two-year period Lower CD4 cell count was significantly associated with a higher risk of VF First ART including mono or dual-NRTI was significantly associated with a higher risk of VF Discussion

7 Acknowledgments Scientific committee S Abgrall, F Barin, M Bentata, E Billaud, F Boué, C Burty, A Cabié, D Costagliola, L Cotte, P De Truchis, X Duval, C Duvivier, P Enel, L Fredouille-Heripret, J Gasnault, C Gaud, J Gilquin, S Grabar, C Katlama, MA Khuong, JM Lang, AS Lascaux, O Launay, A Mahamat, M Mary-Krause, S Matheron, JL Meynard, J Pavie, G Pialoux, F Pilorgé, I Poizot-Martin, C Pradier, J Reynes, E Rouveix, A Simon, P Tattevin, H Tissot-Dupont, JP Viard, N Viget DMI2 coordinating centre French Ministry of Health (D Martin), Technical Hospitalization Information Agency, ATIH (N Jacquemet) Statistical analysis centre U943 INSERM and UPMC (S Abgrall, D Costagliola, S Grabar, M Guiguet, L Lièvre, M Mary- Krause, H Selinger-Leneman), INSERM-Transfert (JM Lacombe, V Potard) Clinical centres –Paris area: Corevih Ile de France Centre (GH Pitié Salpétrière, Hôpital Saint-Antoine, Hôpital Tenon), Corevih Ile de France Est (Hôpital Saint-Louis, GH Lariboisière-Fernand Widal, Hôpital Avicenne, Hôpital Jean Verdier, Hôpital Delafontaine), Corevih Ile de France Nord (Hôpital Bichat-Claude Bernard), Corevih Ile de France Ouest (Hôpital Ambroise Paré, Hôpital Louis Mourier, Hôpital Raymond Poincaré, Argenteuil, Le Chesnay, Mantes la Jolie, Meulan, Nanterre, Poissy, Saint-Germain en Laye, Suresnes,), Corevih Ile de France Sud (Hôpital Européen Georges Pompidou, GH Tarnier-Cochin, Hôpital Necker Hôtel-Dieu, Hôpital Antoine Béclère, Hôpital de Bicêtre, Hôpital Henri Mondor, Hôpital Paul Brousse). –Outside Paris area: Corevih Alsace (CHRU de Strasbourg, CH de Mulhouse), Corevih de lArc Alpin (CHU de Grenoble), Corevih Auvergne-Loire (CHU de Clermont-Ferrand, CHRU de Saint-Etienne), Corevih Basse-Normandie (CHRU de Caen), Corevih Bourgogne (CHRU de Dijon), Corevih Bretagne (CHU de Rennes), Corevih Centre (CHRU de Tours), Corevih Franche-Comté (CHRU de Besançon, CH de Belfort), Corevih Haute-Normandie (CHRU de Rouen), Corevih Languedoc-Roussillon (CHU de Montpellier, CHG de Nîmes), Corevih Lorraine (Nancy Hôpital de Brabois, CHRU de Reims), Corevih de Midi-Pyrénées (Toulouse CHU Purpan, Toulouse Hôpital la Grave, Toulouse CHU Rangueil), Corevih Nord-Pas de Calais (CH de Tourcoing), Corevih PACA Est (Nice Hôpital Archet 1, CHG Antibes-Juan les Pins, Fréjus, Grasse), Corevih PACA Ouest (Marseille Hôpital de la Conception, Marseille Hôpital Nord, Marseille Hôpital Sainte-Marguerite, Marseille Centre pénitentiaire des Baumettes, CHG dAix-En-Provence, CH dArles, CH dAvignon,CH de Digne Les Bains, CH de Gap, CH de Martigues, CHI de Toulon), Corevih Pays de la Loire (CHRU de Nantes), Corevih de la Vallée du Rhône (Lyon Hôpital de la Croix-Rousse, Lyon Hôpital Edouard Herriot, Lyon Hôtel-Dieu) –Overseas: Corevih Guadeloupe (CHRU de Pointe-à-Pitre, CH Saint-Martin), Corevih Guyane (CHG de Cayenne), Corevih Martinique (CHRU de Fort-de-France), Corevih de La Réunion (CHD Félix Guyon)