Cas clinique 6.

CLOTS 3 Effectiveness of intermittent pneumatic compression in reduction of risk of deep venous thrombosis in patients who have had a stroke (CLOTS 3):
STREAM Fibrinolysis or Primary PCI in ST-segment Elevation Myocardial Infarction Armstrong P.W, et al. N Engl J Med 2013 ; 368 : Armstrong PW.
unstable angina undergoing PCI.
EXCELLENT The randomized comparison of 6-month vs 12-month duration of dual antiplatelet therapy after the implantation of drug eluting stent. Gwon H-C,
ISAR-TEST 4 Intracoronary stenting and antirestenotic results : test efficacy of 3 limus-eluting stents Mehilli J et al.
ATOLL Acute STEMI treated with primary PCI and intravenous enoxaparin or UFH to lower ischemic and bleeding events at short and long-term follow-up. Montalescot.
ABOARD* Essai multicentrique randomisé comparant une stratégie invasive immédiate versus différée chez des patients présentant un syndrome coronarien aigu.
ATLAS ACS 2 -TIMI 51 Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome.  Présentée.
TITRATION DU CLOPIDOGREL Tailored Clopidogrel Loading Dose according to Platelet Reactivity Monitoring Decrease Early Stent Thrombosis. Paganelli F et.
Clopidogrel Quand et combien? André Kokis MD FRCPC FACC Hémodynamicien et cardiologue du CHUM.
SYNTAX The synergy between percutaneous coronary intervention with TAXUS and cardiac surgery. Primary endpoint results at one year in the randomized cohort.
CARESS-AMI Combined Abciximab Reteplase Stent Study in Acute Myocardial Infarction ESC CARESS-AMI.
Registre MATRIX Long term safety of DES (drug eluting stents) in off-label use : results of the MATRIX registry. Dangas G.D et al. American College of.
TRITON-TIMI 38 Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes.
ATLANTIC : ticagrelor en traitement pré-hospitalier (2)
ISAR REACT 3A A trial of reduced dose of unfractioned heparin in biomarker negative patients undergoing percutaneous coronary intervention. Schulz S et.
PRODIGY Prolonging dual antiplatelet treatment after grading stent-induced intimal hyperplasia study Valgimigli M et al. ESC 2011.
Mass-DAC Drug-Eluting and Bare Metal Stenting in Diabetes Mellitus : Results from the Mass-DAC Registry. Mauri L et al. AHA 2008.
TRITON-TIMI 38 Evaluation of Prasugrel Compared with Clopidogrel in Patients with Acute Coronary Syndromes and Planned Percutaneous Coronary Intervention:
GRACIA 2 Angioplastie coronaire primaire (ATL I) ou ATL « facilitée » dans le traitement de l’infarctus du myocarde en voie de constitution. ESC, Vienne,
EARLY-ACS Inhibition de la glycoprotéine IIb/IIIa dans le syndrome coronarien aigu sans sus-décalage de ST Newby K et al. ACC Anti-GPIIb/IIIa précoce.
TRITON-TIMI 38 Trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infraction.
Revascularisation coronaire : ATL-endoprothèses ou chirurgie ?
CLOTS 1 Efficacité des bas de contention dans la prévention des thromboses veineuses profondes après un AVC (essai CLOTS 1) : étude multicentrique randomisée.
CRASH-2 Effets de l’acide tranexamique sur la mortalité, les événements cardiovasculaires et la transfusion sanguine chez les patients traumatisés ayant.
HEAT-PPCI Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI) : an open-label, single centre, randomised.
FREEDOM Strategies for Multivessel Revascularization in Patients with Diabetes N Engl J Med 2012 DOI : /NEJMoa Farkouh ME et al. AHA 2012.
Reduction of stent thrombosis in patients with acute coronary syndromes treated with rivaroxaban in ATLAS-ACS TIMI 51 ATLAS ACS 2 –TIMI 51 * Gibson CM.
FAME 2 Fractional Flow Reserve-Guided PCI versus Medical Therapy in Stable Coronary Disease De Bruyne B et al. ESC 2012.
ADVANCE-2 Apixaban versus énoxaparine pour la thromboprophylaxie après prothèse totale du genou (ADVANCE-2): un essai randomisé en double-aveugle Lassen.
MTEV ET CANCER EVOLUTIF Thrombose veineuse chez les patients atteints de cancer évolutif Seddighzadeh A et al. Thromb Haemost 2007; 98: Venous.
JPPP Low-dose aspirin for primary prevention of cardiovascular events in elderly patients with multiple atherosclerotic risk factors. A randomized control.
Prasugrel vs Clopidogrel for Acute Coronary Syndromes without Revascularization TRILOGY ACS Roe MT et al. N Engl J Med 2012 ; 367:
M.Sabry Service des Explorations Cardiologiques Invasives HMIMV Rabat.
MTEV, SURVIE ET MYÉLOME Effet sur la survie d’un événement thromboembolique veineux chez les patients ayant un myélome multiple de diagnostic récent Effect.
ASPIRE Low-dose Aspirin for Preventing Recurrent Venous Thromboembolism N Engl J Med 2012 DOI : /NEJMoa Brighton TA et al. AHA 2012.
Rome – ESC 2016 Marie Viala, CHU Montpellier-Nîmes TDLB
RE-MODEL Study Essai clinique randomisé comparant
WOEST First randomised trial comparing two regimens with and without aspirin in patients on oral anticoagulant therapy undergoing coronary stenting. Dewilde.
X-VERT Explore the efficacy and safety of once-daily oral rivaroxaban for the prevention of cardiovascular events in subjects with non-valvular atrial.
ALTERNATIVE AU KISSING FINAL DANS LE TRAITEMENT DES BIFURCATIONS
Par Magali Laliberté 27 MAI 2016 UMF NOTRE-DAME
Dabigatran versus Warfarin in Patients with Mechanical Heart Valves
Dabigatran versus Warfarin in Patients with Mechanical Heart Valves
ADVANCE-3 Apixaban versus enoxaparin for thromboprophylaxis after hip replacement Lassen MR et al NEJM 2010; 363 :
Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm
Phase 3 long acting rFIX glycoPEG Hémophilie B
ATLAS ACS 2 – TIMI 51 Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome Gibson CM.
1–Thrombolysis in myocardial infarction
ATLANTIC Administration of Ticagrelor in the cath lab or in the ambulance for new ST elevation myocardial infarction to open the coronary artery Montalescot.
IST-3 The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6h of acute ischaemic stroke (the third international.
CALISTO Fondaparinux pour le traitement
ATLAS ACS-TIMI 46 Rivaroxaban versus placebo dans le SCA
3 Karine Gourd R1 Étienne Béliveau Tse R1 UMF de Verdun
WOEST First randomised trial comparing two regimens with and without aspirin in patients on oral anticoagulant therapy undergoing coronary stenting. Dewilde.
Pr L CHRISTIAENS Actualités ESC 2017 Pr L CHRISTIAENS
ACCOAST Pretreatment with prasugrel in non-ST elevation acute coronary syndromes ESC 2013 Montalescot G, et al. N Engl J Med 2013.
AMADEUS Comparaison de l’idraparinux avec les AVK en prévention des accidents thrombo-emboliques de la fibrillation auriculaire : étude randomisée, ouverte,
HOKUSAI-VTE Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism ESC 2013 Büller HR et al. N Engl J Med 2013 ; 369 :
CMD non-ischémique & DAI ESC congress 2016
Platelet inhibition and patient outcomes
Strategies for Multivessel Revascularization in Patients with Diabetes
Réponse aux questionnaires :
TRA 2° P Vorapaxar in the secondary prevention in atherothrombotic events Morrow DA et al. N Engl J Med 2012 ; 366 : Morrow DA et al. ACC 2012.
Host-ASSURE Adjunctive Cilostazol vs double dose clopidogrel after PCI with drug eluting stent Hyo-Soo K et al. ACC 2012.
(étude de phase II randomisée)
Principaux critères d’inclusion
TRILOGY ACS Prasugrel vs Clopidogrel for Acute Coronary Syndromes Patients managed without Revascularization. Ohman M, et al. ESC 2012.
PROTECT Stent thrombosis and major clinical events at 3 years after zotarolimus-eluting or sirolimus-eluting coronary stent implantation : a randomised.